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Báo cáo y học: " Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2 fragments"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2 fragments. | Available online http arthritis-research.eom content 10 4 R88 Research article Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40 Pregq2 fragments Maria Liljander1 Ảsa Andersson2 Rikard Holmdahl3 4 and Ragnar Mattsson1 1Lund Transgenic Core Facility BMC C13 Lund University Klinikgatan 28 SE-221 84 Lund Sweden 2Department of Pharmacology and Pharmacotherapy Group of Molecular Immunopharmacology Faculty of Pharmaceutical Sciences Copenhagen University Universitetsparken 2 DK-2100 Copenhagen 0 Denmark 3Medical Inflammation Research Lund University BMC I11 SE-221 84 Lund Sweden 4Karolinska Institute Division of Medical Inflammation Research Sheeles vag 2 SE-171 77 Stockholm Sweden Corresponding author Maria Liljander maria.liljander@med.lu.se Received 20 Feb 2008 Revisions requested 1 Apr 2008 Revisions received 24 Jun 2008 Accepted 6 Aug 2008 Published 6 Aug 2008 Arthritis Research Therapy 2008 10 R88 doi 10.1186 ar2470 This article is online at http arthritis-research.com content 10 4 R88 2008 Liljander et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Collagen-induced arthritis CIA in mice is a commonly used experimental model for rheumatoid arthritis RA . We have previously identified a significant quantitative trait locus denoted Cia40 on chromosome 11 that affects CIA in older female mice. This locus colocalizes with another locus denoted Pregq2 known to affect reproductive success. The present study was performed to evaluate the role of the Cia40 locus in congenic B10.Q mice and to identify possible polymorphic candidate genes which may also be relevant in the context of RA. Methods Congenic B10.Q mice carrying an NFR N fragment surrounding