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Báo cáo y học: "Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity. | Available online http arthritis-research.eom content 11 4 R101 Research article Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity Éric Toussirot1 2 3 Philippe Saas4 Marina Deschamps4 Fabienne Pouthier5 Lucille Perrot3 4 Sylvain Perruche4 Jacqueline Chabod5 Pierre Tiberghien4 5 and Daniel Wendling1 2 Department of Rheumatology University Hospital Jean Minjoz Bd Fleming 25030 Besanọon cedex France 2EA 31 86 Agents Pathogènes et Inflammation University of Franche-Comté IFR133 Place St Jacques Besanọon France 3CIC-Biotherapy 506 University Hospital St-Jacques Place St Jacques 25030 Besanọon cedex France 4INSERM UMR645 University of Franche-Comté EFS Bourgogne Franche-Comté Plateforme de Biomonitoring CIC-Biotherapy 506 IFR133 Bd Fleming 25020 Besanọon cedex France 5EFS Bourgogne Franche-Comté Bd Fleming 25020 Besanọon cedex France Contributed equally Corresponding author Éric Toussirot etoussirot@chu-besancon.fr Received 17 Dec 2008 Revisions requested 3 Feb 2009 Revisions received 6 Jun 2009 Accepted 1 Jul 2009 Published 1 Jul 2009 Arthritis Research Therapy 2009 11 R101 doi 10.11 86 ar2747 This article is online at http arthritis-research.com content 11 4 R101 2009 Toussirot et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Spondylarthropathies SpA are characterized by abnormal immune responses including T cell activation. Cytotoxic T lymphocyte associated molecule-4 CTLA-4 is involved in down-regulating immune responses. A soluble form of CTLA-4 sCTLA-4 resulting from an alternative splicing has been identified and was found increased in several autoimmune diseases. Here we evaluated circulating levels of sCTLA-4 as a marker of