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Báo cáo y học: "Predictors of major infections in systemic lupus erythematosus"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Predictors of major infections in systemic lupus erythematosus. | Available online http arthritis-research.eom content 11 4 R109 Research article Predictors of major infections in systemic lupus erythematosus Guillermo Ruiz-Irastorza Nerea Olivares loana Ruiz-Arruza Agustin Martinez-Berriotxoa Maria-Victoria Egurbide and Ciriaco Aguirre Department of Internal Medicine Hospital de Cruces University of the Basque Country Pza Cruces s n 48903 Barakaldo Bizkaia Spain Corresponding author Guillermo Ruiz-lrastorza r.irastorza@euskalnet.net Received 17 Jan 2009 Revisions requested 10 Mar 2009 Revisions received 28 Apr 2009 Accepted 15 Jul 2009 Published 15 Jul 2009 Arthritis Research Therapy 2009 11 R109 doi 10.11 86 ar2764 This article is online at http arthritis-research.com content 11 4 R109 2009 Ruiz-lrastorza et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Infections commonly complicate the course of systemic lupus erythematosus SLE . Our aim is to investigate the clinical predictors of major infections in patients with SLE. Methods A nested case-control study design was used within the prospective Lupus-Cruces cohort. The endpoints of the study were major infections. Cases were defined as patients with a major infection. Two controls SLE patients without major infections matched for time of follow-up until the event and age at diagnosis were selected for each case. Univariate analysis and logistic regression models were used for the analysis of data. Results Two hundred and forty-nine patients 83 cases 166 controls were selected. Eighty-three episodes of major infections were analyzed E. coli S. aureus M. tuberculosis and S. pneumoniae being the most frequent isolates. Univariate analysis identified several variables related with infection lung and

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