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Báo cáo y học: "Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study. | Available online http arthritis-research.eom content 11 5 R154 Research article Relationship between anti-dsDNA anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis a prospective longitudinal study Jessica J Manson1 Alexander Ma1 Pauline Rogers2 Lesley J Mason1 Jo H Berden3 Johan van der Vlag3 David P D Cruz4 David A Isenberg1 and Anisur Rahman1 1Centre for Rheumatology Research University College London Windeyer Institute 46 Cleveland Street London W1T 4JF UK 2Joint University College London Hospital University College London and Royal Free Biomedical Research Unit Research and Development 1st Floor Maple House Rosenheim Wing 25 Grafton Way London WC1E 6DB UK 3Nephrology Research Laboratory Nijmegen Centre for Molecular Life Sciences Department of Nephrology Radboud University Nijmegen Medical Centre PO Box 9101 6500 HB Nijmegen The Netherlands 4Lupus Research Unit The Rayne Institute St Thomas Hospital Lambeth Palace Road London SE1 7EH UK Corresponding author Anisur Rahman anisur.rahman@ucl.ac.uk Received 12 Aug 2009 Revisions requested 22 Sep 2009 Revisions received 3 Oct 2009 Accepted 14 Oct 2009 Published 14 Oct 2009 Arthritis Research Therapy 2009 11 R154 doi 10.11 86 ar2831 This article is online at http arthritis-research.com content 11 5 R154 2009 Manson et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Glomerulonephritis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus SLE . Deposition of autoantibodies in the glomeruli plays a key role in the development of lupus nephritis LN . Different groups have proposed that either anti-nucleosome antibodies or antibodies that bind the .