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Báo cáo y học: "Transcriptional profiling of the nucleus pulposus: say yes to notochord"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Transcriptional profiling of the nucleus pulposus: say yes to notochord. | Shapiro and Risbud Arthritis Research Therapy 2010 12 117 http arthritis-research.eom content 12 3 117 EDITORIAL L_ Transcriptional profiling of the nucleus pulposus say yes to notochord Irving M Shapiro and Makarand V Risbud See related research by Minogue etal. http arthritis-research.eom content 12 1 R22 Abstract This editorial addresses the debate concerning the origin of adult nucleus pulposus cells in the light of profiling studies by Minogue and colleagues. In their report of several marker genes that distinguish nucleus pulposus cells from other related cell types the authors provide novel insights into the notochordal nature of the former. Together with recently published work their work lends support to the view that all cells present within the nucleus pulposus are derived from the notochord. Hence the choice of an animal model for disc research should be based on considerations other than the cell loss and replacement by non-notochordal cells. Despite many concerns profiling has been used successfully to identify or predict possible antisocial behaviors. Profiling relies on highlighting unique traits against a background of confounding signals. Similarly transcriptional profiling is a powerful technique to determine marker genes that characterize and distinguish a particular cell type. In a recent issue of Arthritis Research Therapy Minogue and colleagues 1 used transcriptional profiling to examine the phenotypic characteristics of bovine intervertebral disc cells and provided some novel insights into the current debate concerning the origin of cells of the adult nucleus pulposus. One aspect of this ongoing controversy is whether the onset of degenerative disc disease is due to the loss of the original notochordal cells or to the replacement of them by unrelated cell types or to both 2 . This dispute affects investigational strategies in which the choice of animal model for a study is governed by the consideration of whether notochordal cells .