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Báo cáo y học: " Cardiovascular and musculoskeletal co-morbidities in patients with alpha 1 antitrypsin deficiency"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Cardiovascular and musculoskeletal co-morbidities in patients with alpha 1 antitrypsin deficiency. | Duckers et al. Respiratory Research 2010 11 173 http respiratory-research.eom content 11 1 173 RESPIRATORY RESEARCH RESEARCH Open Access Cardiovascular and musculoskeletal co-morbidities in patients with alpha 1 antitrypsin deficiency James M Duckers 1 Dennis J Shale1 Robert A Stockley2 Nichola S Gale1 Bronwen AJ Evans3 John R Cockcroft4 and Charlotte E Bolton1 5 Abstract Background Determining the presence and extent of co-morbidities is fundamental in assessing patients with chronic respiratory disease where increased cardiovascular risk presence of osteoporosis and low muscle mass have been recognised in several disease states. We hypothesised that the systemic consequences are evident in a further group of subjects with COPD due to Alpha-1 Antitrypsin Deficiency A1ATD yet are currently underrecognised. Methods We studied 19 patients with PiZZ A1ATD COPD and 20 age sex and smoking matched controls all subjects free from known cardiovascular disease. They underwent spirometry haemodynamic measurements including aortic pulse wave velocity aPWV an independent predictor or cardiovascular risk dual energy X-ray absorptiometry to determine body composition and bone mineral density. Results The aPWV was greater in patients 9.9 2.1 m s than controls 8.5 1.6 m s p 0.03 despite similar mean arterial pressure MAP . The strongest predictors of aPWV were age FEV1 predicted and MAP all p 0.01 . Osteoporosis was present in 8 19 patients 2 20 controls and was previously unsuspected in 7 patients. The fat free mass and bone mineral density were lower in patients than controls p 0.001 . Conclusions Patients with A1ATD related COPD have increased aortic stiffness suggesting increased risk of cardiovascular disease and evidence of occult musculoskeletal changes all likely to contribute hugely to overall morbidity and mortality. Background The systemic manifestations in chronic respiratory conditions such as chronic obstructive pulmonary disease COPD can be multiple and include a .