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Báo cáo y học: " Particles induce apical plasma membrane enlargement in epithelial lung cell line depending on particle surface area dose"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"" Particles induce apical plasma membrane enlargement in epithelial lung cell line depending on particle surface area dose. | Respiratory Research BioMed Central Open Access Particles induce apical plasma membrane enlargement in epithelial lung cell line depending on particle surface area dose Christina Brandenberger 1 Barbara Rothen-Rutishauser1 Fabian Blank1 2 Peter Gehr1 and Christian Muhlfeld1 3 Address 1Institute of Anatomy University of Bern Baltzerstrasse 2 CH-3000 Bern 9 Switzerland 2Telethon Institute for Child Health Research 100 Roberts Road Subiaco Perth WA 6008 Australia and Institute of Anatomy and Cell Biology Justus-Liebig-University Giessen Aulweg 123 D-35385 Giessen Germany Email Christina Brandenberger - brandenberger@ana.unibe.ch Barbara Rothen-Rutishauser - rothen@ana.unibe.ch Fabian Blank - fblank@ichr.uwa.edu.au Peter Gehr - gehr@ana.unibe.ch Christian Muhlfeld - Christian.Muehlfeld@anatomie.med.uni-giessen.de Corresponding author Published 12 March 2009 Received 25 August 2008 Respiratory Research 2009 10 22 doi l0.ll86 l465-992l-l0-22 Accepted 12 March 2009 This article is available from http respiratory-research.cOm content l0 l 22 2009 Brandenberger et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Airborne particles entering the respiratory tract may interact with the apical plasma membrane APM of epithelial cells and enter them. Differences in the entering mechanisms of fine between 0. l pm and 2.5 pm and ultrafine 0.l pm particles may be associated with different effects on the APM. Therefore we studied particle-induced changes in APM surface area in relation to applied and intracellular particle size surface and number. Methods Human pulmonary epithelial cells A549 cell line were incubated with various concentrations of different sized fluorescent polystyrene spheres without surface charge 0 .