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Báo cáo y học: " Allergic lung inflammation alters neither susceptibility to Streptococcus pneumoniae infection nor inducibility of innate resistance in mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Allergic lung inflammation alters neither susceptibility to Streptococcus pneumoniae infection nor inducibility of innate resistance in mice. | Respiratory Research BioMed Central Open Access Allergic lung inflammation alters neither susceptibility to Streptococcus pneumoniae infection nor inducibility of innate resistance in mice Cecilia G Clement1 2 Michael J Tuvim1 2 Christopher M Evans1 2 Daniel M Tuvin1 2 Burton F Dickey1 2 and Scott E Evans 1 2 Address Department of Pulmonary Medicine The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA and 2Center for Lung Inflammation and Infection Institute of Biosciences and Technology Texas A M Health Science Center 2121 Holcombe Boulevard Houston Tx 77030 USA Email Cecilia G Clement - cgmoron@utmb.edu Michael J Tuvim - mtuvim@mdanderson.org Christopher M Evans - cevans@mdanderson.org Daniel M Tuvin - dtuvin@gmail.com Burton F Dickey - bdickey@mdanderson.org Scott E Evans - seevans@mdanderson.org Corresponding author Published 27 July 2009 Received 29 April 2009 Respiratory Research 2009 10 70 doi 10.1186 1465-9921-10-70 Accepted 27 July 2009 This article is available from http respiratory-research.com content 10 1 70 2009 Clement et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Protective host responses to respiratory pathogens are typically characterized by inflammation. However lung inflammation is not always protective and it may even become deleterious to the host. We have recently reported substantial protection against Streptococcus pneumoniae pneumococcal pneumonia by induction of a robust inflammatory innate immune response to an inhaled bacterial lysate. Conversely the allergic inflammation associated with asthma has been proposed to promote susceptibility to pneumococcal disease. This study sought to determine whether preexisting allergic .