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Báo cáo y học: " Systemic T-helper and T-regulatory cell type cytokine responses in rhinovirus vs. respiratory syncytial virus induced early wheezing: an observational study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Systemic T-helper and T-regulatory cell type cytokine responses in rhinovirus vs. respiratory syncytial virus induced early wheezing: an observational study. | Respiratory Research BioMed Central Open Access Systemic T-helper and T-regulatory cell type cytokine responses in rhinovirus vs. respiratory syncytial virus induced early wheezing an observational study Tuomas Jartti 1 Maria Paul-Anttila2 Pasi Lehtinen1 Vilhelmiina Parikka1 Tytti Vuorinen2 Olli Simell1 and Olli Ruuskanen1 Address Department of Pediatrics Turku University Hospital Turku Finland and 2Department of Virology University of Turku Turku Finland Email Tuomas Jartti - tuomas.jartti@utu.fi Maria Paul-Anttila - mpaul.anttila@gmail.com Pasi Lehtinen - pasi.lehtinen@utu.fi Vilhelmiina Parikka - vilhelmiina.parikka@utu.fi Tytti Vuorinen - tytti.vuorinen@utu.fi Olli Simell - olli.simell@utu.fi Olli Ruuskanen - olli.ruuskanen@tyks.fi Corresponding author Published 25 September 2009 Received 21 March 2009 Respiratory Research 2009 10 85 doi l0.ll86 l465-992l-l0-85 Accepted 25 September 2009 This article is available from http respiratory-research.cOm content l0 l 85 2009 Jartti et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Rhinovirus RV associated early wheezing has been recognized as an independent risk factor for asthma. The risk is more important than that associated with respiratory syncytial virus RSV disease. No comparative data are available on the immune responses of these diseases. Objective To compare T-helperl Thl Th2 and T-regulatory Treg cell type cytokine responses between RV and RSV induced early wheezing. Methods Systemic Thl-type interferon IFN -gamma interleukin IL -2 IL-12 Th2-type IL-4 IL-5 IL-13 and Treg-type IL-10 cytokine responses were studied from acute and convalescence phase serum samples of sole RV n 23 and RSV affected hospitalized wheezing children n 27 . The .