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Báo cáo y học: " A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease. | Respiratory Research BioMed Central Research Open Access A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease Nicholas S Hopkinson 1 Rachel C Tennant2 Mark J Dayer1 Elisabeth B Swallow1 Trevor T Hansel2 John Moxham3 and Michael I Polkey1 Address Respiratory Muscle Laboratory Royal Brompton Hospital Fulham Rd London SW3 6NP UK 2Clinical Studies Unit National Heart and Lung Institute Royal Brompton Hospital Fulham Rd London SW3 6NP UK and 3Respiratory Muscle Laboratory Guy s King s and St Thomas School of Medicine King s College Hospital Denmark Hill London SE5 9RS UK Email Nicholas S Hopkinson - n.hopkinson@ic.ac.uk Rachel C Tennant - r.tennant@ic.ac.uk Mark J Dayer - mdayer@gmail.com Elisabeth B Swallow - e.swallow@ic.ac.uk Trevor T Hansel - t.hansel@ic.ac.uk John Moxham - john.moxham@kcl.ac.uk Michael I Polkey - m.polkey@rbht.nhs.uk Corresponding author Published 13 March 2007 Respiratory Research 2007 8 25 doi 10.1186 1465-9921 -8-25 Received 27 October 2006 Accepted 13 March 2007 This article is available from http respiratory-research.cOm content 8 1 25 2007 Hopkinson et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Skeletal muscle depletion is an important complication of chronic obstructive pulmonary disease COPD but little prospective data exists about the rate at which it occurs and the factors that promote its development. We therefore prospectively investigated the impact of disease severity exacerbation frequency and treatment with corticosteroids on change in body composition and maximum isometric quadriceps strength QMVC over one year. Methods 64 patients with stable COPD FEV1 mean SD 35.8 18.4 predicted were recruited .