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Báo cáo y học: " LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms. | Respiratory Research BioMed Central Research Open Access LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms Hugues Chanteux Amélie C Guisset Charles Pilette and Yves Sibille Address Unit of microbiology Université Catholique de Louvain Av Hippocrate 54 B-1200 Brussels Belgium Email Hugues Chanteux- hugues.chanteux@ucb-group.com Amélie C Guisset- amelie.guisset@mblg.ucl.ac.be Charles Pilette - charles.pilette@pneu.ucl.ac.be Yves Sibille - sibille@mblg.ucl.ac.be Corresponding author Published 4 October 2007 Received 21 September 2006 Respiratory Research 2007 8 71 doi 10.1186 1465-9921 -8-71 Accepted 4 October 2007 This article is available from http respiratory-research.cOm content 8 1 71 2007 Chanteux et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background IL-10 is a cytokine mainly produced by macrophages that plays key roles in tolerance to inhaled antigens and in lung homeostasis. Its regulation in alveolar macrophages HAM the resident lung phagocytes remains however unknown. Methods The present study investigated the role of intracellular signalling and transcription factors controlling the production of IL-10 in LPS-activated HAM from normal nonsmoking volunteers. Results LPS 1-1000 pg ml induced in vitro IL-10 production by HAM both at mRNA and protein levels. LPS also activated the phosphorylation of ERK p38 and JNK MAPkinases immunoblots and Sp-1 nuclear activity EMSA . Selective inhibitors of MAPKinases respectively PD98059 SB203580 and SP600125 and of Sp-1 signaling mithramycin decreased IL-10 expression in HAM. In addition whilst not affecting IL-10 mRNA degradation the three MAPKinase inhibitors completely abolished Sp-1 activation by LPS in

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