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Báo cáo y học: " Peripheral blood B lymphocytes derived from patients with idiopathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls: a cross sectional study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Peripheral blood B lymphocytes derived from patients with idiopathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls: a cross sectional study. | Respiratory Research BioMed Central Open Access Peripheral blood B lymphocytes derived from patients with idiopathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls a cross sectional study Silvia Ulrich 1 2 Laima Taraseviciene-Stewart2 Lars C Huber1 Rudolf Speich1 and Norbert Voelkel2 Address Department of Internal Medicine Pulmonary Hypertension Clinic University Hospital of Zurich Zurich Switzerland and 2Department of Medicine Pulmonary Sciences and Critical Care Medicine University of Colorado Health Sciences Centre Denver Colorado USA Email Silvia Ulrich - ulris@bluewin.ch LaimaTaraseviciene-Stewart-laima.taraseviciene@uchsc.edu Lars C Huber - lars.huber@usz.ch Rudolf Speich - rudolf.speich@usz.ch Norbert Voelkel - nvoelkel@mcvh-vcu.edu Corresponding author Published 12 February 2008 Received 17 December 2007 Respiratory Research 2008 9 20 doi 10.1186 1465-9921 -9-20 Accepted 12 February 2008 This article is available from http respiratory-research.cOm content 9 1 20 2008 Ulrich et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Idiopathic pulmonary arterial hypertension IPAH is a progressive and still incurable disease. Research of IPAH-pathogenesis is complicated by the lack of a direct access to the involved tissue the human pulmonary vasculature. Various auto-antibodies have been described in the blood of patients with IPAH. The purpose of the present work was therefore to comparatively analyze peripheral blood B lymphocyte RNA expression characteristics in IPAH and healthy controls. Methods Patients were diagnosed having IPAH according to WHO mean pulmonary arterial pressure 25 mmHg pulmonary capillary occlusion pressure 15 mmHg absence of .