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Báo cáo y học: "Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study. | Respiratory Research BioMed Central Research Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease an ex vivo study Tillie-Louise Hackett 1 Rebecca Holloway1 Stephen T Holgate2 and Jane A Warner1 Address 1School of Biological Sciences University of Southampton Southampton UK and 2Infection Inflammation and Repair Division Southampton General hospital Southampton UK Email Tillie-Louise Hackett - thackett@mrl.ubc.ca Rebecca Holloway - rh702@soton.ac.uk Stephen T Holgate - S.Holgate@soton.ac.uk Jane A Warner - jawarner@soton.ac.uk Corresponding author Open Access Published 29 May 2008 Received 12 December 2007 Respiratory Research 2008 9 47 doi 10.1186 1465-9921 -9-47 Accepted 29 May 2008 This article is available from http respiratory-research.cOm content 9 1 47 2008 Hackett et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Exacerbations of Chronic obstructive pulmonary disease COPD are an important cause of the morbidity and mortality associated with the disease. Strategies to reduce exacerbation frequency are thus urgently required and depend on an understanding of the inflammatory milieu associated with exacerbation episodes. Bacterial colonisation has been shown to be related to the degree of airflow obstruction and increased exacerbation frequency. The aim of this study was to asses the kinetics of cytokine release from COPD parenchymal explants using an ex vivo model of lipopolysaccharide LPS induced acute inflammation. Methods Lung tissue from 24 patients classified by the GOLD guidelines 7F 17M age 67.9 2.0 yrs FEVI 76.3 3.5 of predicted and 13 subjects with normal lung function 8F 5M age 55.6 4.1 yrs FEVI 98.8 4.1