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Báo cáo y học: "Inhaled nitric oxide alleviates hyperoxia suppressed phosphatidylcholine synthesis in endotoxin-induced injury in mature rat lungs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Inhaled nitric oxide alleviates hyperoxia suppressed phosphatidylcholine synthesis in endotoxin-induced injury in mature rat lungs. | Respiratory Research BioMed Central Research Open Access Inhaled nitric oxide alleviates hyperoxia suppressed phosphatidylcholine synthesis in endotoxin-induced injury in mature rat lungs Xiaohui Gong Chunbao Guo Shibing Huang and Bo Sun Address Laboratory of Respiratory and Intensive Care Medicine Children s Hospital of Fudan University Shanghai 200032 P. R. China Email Xiaohui Gong - xiaohui_gong@sina.com Chunbao Guo - Chunbao.guo@yahoo.com.cn Shibing Huang - shibing.huang@yahoo.com.cn Bo Sun - qyang75@yahoo.com.cn Corresponding author Published II January 2006 Received 05 August 2005 Respiratory Research 2006 7 5 doi 10.1186 1465-9921-7-5 Accepted 1 1 January 2006 This article is available from http respiratory-research.com content 7 I 5 2006 Gong et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background We investigated efficacy of inhaled nitric oxide NO in modulation of metabolism of phosphatidylcholine PC of pulmonary surfactant and in anti-inflammatory mechanism of mature lungs with inflammatory injury. Methods Healthy adult rats were divided into a group of lung inflammation induced by i.v. lipopolysaccharides LPS or a normal control C for 24 h and then exposed to room air Air 95 oxygen O NO 20 parts per million NO both O and NO ONO as subgroups whereas 3H -choline was injected i.v. for incorporation into PC of the lungs which were processed subsequently at 10 min 4 8 12 and 24 h respectively for measurement of PC synthesis and proinflammatory cytokine production. Results LPS-NO subgroup had the lowest level of labeled PC in total phospholipids and disaturated PC in bronchoalveolar lavage fluid and lung tissue decreased by 46-59 along with the lowest activity of cytidine triphosphate phosphocholine .