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Báo cáo y học: "Biochemical and morphological changes in endothelial cells in response to hypoxic interstitial edema"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Biochemical and morphological changes in endothelial cells in response to hypoxic interstitial edema. | Respiratory Research BioMed Central Research Open Access Biochemical and morphological changes in endothelial cells in response to hypoxic interstitial edema Laura Botto Egidio Beretta Rossella Daffara Giuseppe Miserocchi and Paola Palestini Address Department of Experimental Environmental Medicine and Biotechnologies DIMESAB University of Milano-Bicocca Via Cadore 48 20052 Monza Italy Email Laura Botto - laura.botto@unimib.it Egidio Beretta - egidio.beretta@unimib.it Rossella Daffara - rossella.daffara@unimib.it Giuseppe Miserocchi - giuseppe.miserocchi@unimib.it Paola Palestini - paola.palestini@unimib.it Corresponding author Published 13 January 2006 Received 28 October 2005 Respiratory Research 2006 7 7 doi l0.ll86 l465-992l-7-7 Accepted 13 January 2006 This article is available from http respiratory-research.cOm content 7 l 7 2006 Botto et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A correlation between interstial pulmonary matrix disorganization and lung cellular response was recently documented in cardiogenic interstitial edema as changes in the signal-cellular transduction platforms lipid microdomains caveoale and lipid rafts . These findings led to hypothesize a specific sensing function by lung cells resulting from a perturbation in cell-matrix interaction. We reason that the cell-matrix interaction may differ between the cardiogenic and the hypoxic type of lung edema due to the observed difference in the sequential degradation of matrix proteoglycans PGs family. In cardiogenic edema a major fragmentation of high molecular weight PGs of the interfibrillar matrix was found while in hypoxia the fragmentation process mostly involved the PGs of the basement membrane controlling .