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Báo cáo y học: " Effects of overexpression of IL-10, IL-12, TGF-β and IL-4 on allergen induced change in bronchial responsiveness"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Effects of overexpression of IL-10, IL-12, TGF-β and IL-4 on allergen induced change in bronchial responsiveness. | Respiratory Research BioMed Central Research Open Access Effects of overexpression of IL-10 IL-12 TGF-p and IL-4 on allergen induced change in bronchial responsiveness Chi-Ling Fu1 Yi-Ling Ye1 Yueh-Lun Lee2 and Bor-Luen Chiang 3 Address Graduate Institute of Immunology College of Medicine National Taiwan University Taiwan Republic of China 2Department of Microbiology and Immunology Taipei Medical University Taiwan Republic of China and 3Department of Pediatrics National Taiwan University Hospital Taiwan Republic of China Email Chi-Ling Fu - d89449001@ntu.edu.tw Yi-Ling Ye - yilingye@yahoo.com.tw Yueh-Lun Lee - yllee@tmu.edu.tw Bor- Luen Chiang - gicmbor@ha.mc.ntu.edu.tw Corresponding author Published 08 May 2006 Received 22 November 2005 Respiratory Research 2006 7 72 doi 10.1186 1465-9921 -7-72 Accepted 08 May 2006 This article is available from http respiratory-research.cOm content 7 1 72 2006 Fu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background An increasing prevalence of allergic diseases such as atopic dermatitis allergic rhinitis and bronchial asthma has been noted worldwide. Allergic asthma strongly correlates with airway inflammation caused by the unregulated production of cytokines secreted by allergenspecific type-2 T helper Th2 cells. This study aims to explore the therapeutic effect of the airway gene transfer of IL-12 IL-10 and TGF-P on airway inflammation in a mouse model of allergic asthma. Methods BALB c mice were sensitized to ovalbumin OVA by intraperitoneal injections with OVA and challenged by nebulized OVA. Different cytokine gene plasmids or non-coding vector plasmids were instilled daily into the trachea up to one day before the inhalatory OVA challenge phase. Results .