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Báo cáo y học: "Spinal afferent neurons projecting to the rat lung and pleura express acid sensitive channels"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Spinal afferent neurons projecting to the rat lung and pleura express acid sensitive channels. | Respiratory Research BioMed Central Research Open Access Spinal afferent neurons projecting to the rat lung and pleura express acid sensitive channels Michael Groth11 Tanja Helbig11 Veronika Grau2 Wolfgang Kummer1 and Rainer V Haberberger 2 Address 1Institute for Anatomy and Cell Biology University of Giessen Lung Center Justus-Liebig-University Giessen Germany and 2Department of General and Thoracic Surgery Laboratory of Experimental Surgery University of Giessen Lung Center Justus-Liebig-University Giessen Germany Email Michael Groth - Migro@gmx.de Tanja Helbig - Tanja.Helbig@gmx.de Veronika Grau - Veronika.Grau@chiru.med.uni-giessen.de Wolfgang Kummer - wolfgang.kummer@anatomie.med.uni-giessen.de Rainer V Haberberger - rainer.haberberger@flinders.edu.au Corresponding author tEqual contributors Published 01 July 2006 Received 14 March 2006 Respiratory Research 2006 7 96 doi 10.1186 1465-9921 -7-96 Accepted 01 July 2006 This article is available from http respiratory-research.cOm content 7 1 96 2006 Groth et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The acid sensitive ion channels TRPV1 transient receptor potential vanilloid receptor-1 and ASIC3 acid sensing ion channel-3 respond to tissue acidification in the range that occurs during painful conditions such as inflammation and ischemia. Here we investigated to which extent they are expressed by rat dorsal root ganglion neurons projecting to lung and pleura respectively. Methods The tracer DiI was either injected into the left lung or applied to the costal pleura. Retrogradely labelled dorsal root ganglion neurons were subjected to triple-labelling immunohistochemistry using antisera against TRPV1 ASIC3 and neurofilament 68 marker for .