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Báo cáo y học: "Challenges in understanding Sjögren’s syndrome – improved insights into the pathogenesis generate hope for innovative therapie"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Challenges in understanding Sjögren’s syndrome – improved insights into the pathogenesis generate hope for innovative therapies? | Dorner Arthritis Research Therapy 2011 13 123 http arthritis-research.eom content 13 4 123 EDITORIAL L_ Challenges in understanding Sjogren s syndrome -improved insights into the pathogenesis generate hope for innovative therapies Thomas Dorner See related reviews by Jacob and Stohl http arthritis-research.eom content 13 4 228 Shao and Cohen http arthritis-research.com content 13 1 202 Holle etal. http arthritis-research.com content 13 3 224 Sipsas etal. http arthritis-research.com content 13 2 212 Vitali http arthritis-research.com content 13 4 233 Low and Witte http arthritis-research.com content 13 3 218 Youinou and Pers http arthritis-research.com content 13 4 227 Delaleu etal. http arthritis-research.com content 13 3 217 and Kallenberg etal. http arthritis-research.com content 13 1 205. Abstract The reviews in this series on Sjogren syndrome provide an up-to-date summary and perspectives on the pathogenesis of this interesting entity with glandular and frequently systemic manifestations the value of preclinical models and our current understanding of therapeutic approaches. The last of these includes what has been learned from trials blocking tumor necrosis factor and more recently anti-CD20 therapy. Potential therapeutic targets such as blockade of the B cell-activating factor the role of interferon-alpha and targeting CD22 are discussed. This series on Sjogren syndrome like disease-oriented review series on systemic lupus erythematosus SLE 1 2 vasculitides and comorbidities of rheumatic conditions 3 consists of articles that review recent topics bring us up to date and provide innovative views 4-8 . Respected researchers of rheumatology and clinical immunology with a great deal of experience in this particular systemic disease provide these overviews and share their perspectives. It is notable that the advent of innovative immune interventions in rheumatoid arthritis within the last decade and the recent approval of the antiB cell-activating factor