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Báo cáo y học: "Inhaled nitric oxide reverses cell-free hemoglobin-induced pulmonary hypertension and decreased lung compliance. Preliminary result"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Inhaled nitric oxide reverses cell-free hemoglobin-induced pulmonary hypertension and decreased lung compliance. Preliminary results. | Available online http ccforum.eom content 1 3 111 Research Inhaled nitric oxide reverses cell-free hemoglobin-induced pulmonary hypertension and decreased lung compliance. Preliminary results Luiz F Poli de Figueiredo1 Mali Mathru2 Jaclyn R Jones3 Daneshvari Solanki2 and George C Kramer2 Department of Cardiopneumology DEX-Instituto do Coraọão Faculdade do Medicina Universidade de São Paulo SP Brazil. 2Department of Anesthesiology Univ. of Texas Medical Branch Galveston TX USA. 3Department of Pulmonary Care Services Univ. of Texas Medical Branch Galveston TX USA. Received 8 May 1997 Revisions requested 5 September 1997 Revisions received 10 December 1997 Accepted 11 December 1997 Published 22 January 1998 1997 Current Science Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Crit Care 1997 1 111 Abstract Background In order to test the hypothesis that inhaled nitric oxide NO reverses the pulmonary hypertension induced by aa-diaspirin crosslinked hemoglobin aaHb were studied anesthetized pigs that were administered with a total dose of 200 mg kg of 10 aaHb. Inhaled NO 5 ppm was administered for 10 min and then discontinued for 10 min. This cycle was then repeated with 10 ppm inhaled NO. Results aaHb caused pulmonary arterial pressure PAP to increase from 27 1.7 to 40 3.0 mmHg P 0.05 and dynamic lung compliance to decrease from 29 1.5 to 23 1.6 ml cmH2O P 0.05 . After both doses of inhaled NO but particularly 10 ppm PAP was reduced P 0.05 and lung compliance increased P 0.05 from the aaHb levels. When inhaled NO was discontinued PAP again increased and lung compliance decreased to levels significantly different from baseline P 0.05 . Conclusion We conclude that cell-free hemoglobin-induced pulmonary hypertension and decreased lung compliance can be selectively counteracted by inhaled NO. Keywords blood substitutes hemoglobin nitric oxide toxicity vasoconstriction Introduction Cell-free hemoglobin oxygen-carrying solutions are now undergoing clinical trials. Such .