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Báo cáo y học: "High frequency oscillatory ventilation attenuates the activation of alveolar macrophages and neutrophils in lung injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: High frequency oscillatory ventilation attenuates the activation of alveolar macrophages and neutrophils in lung injury. | Available online http ccforum.eom content 2 1 35 Research High frequency oscillatory ventilation attenuates the activation of alveolar macrophages and neutrophils in lung injury Motomu Shimaoku1 Yuji Fujino1 Nobuyuki Taenaka1 Takachika Hiroi2 Hiroshi Kiyono2 and Ikuto Yoshiya1 intensive Care Unit Osaka University Hospital Osaka University Yamadaoka Suita Osaka 565 Japan. 2Research Institute for Microbial Diseases Osaka University Yamadaoka Suita Osaka 565 Japan. Received 8 September 1 997 Revisions requested 17 November 1997 Revisions received 30 January 1998 Accepted 2 February 1998 Published 12 March 1998 1998 Current Science Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Crit Care 1998 2 35 Abstract Background Recent investigations have shown that leukocyte activation is involved in the pathogenesis of ventilator-associated lung injury. This study was designed to investigate whether the inflammatory responses and deterioration of oxygenation in ventilator-associated lung injury are attenuated by high-frequency oscillatory ventilation HFO . We analyzed the effects of HFO compared with conventional mechanical ventilation CMV on the activation of pulmonary macrophages and neutrophils in 10 female rabbits. Results After surfactant depletion the rabbits were ventilated by CMV or HFO at the same mean airway pressure. Surfactant-depletion followed by 4 h mechanical ventilation hindered pulmonary oxygenation in both groups. Impairment of oxygenation was less severe in the HFO group than in the CMV group. In the HFO group the infiltration of granulocytes into alveolar spaces occurred more readily than in the CMV group compared with CMV HFO resulted in greater attenuation of p2-integrin expression not only on granulocytes but also on macrophages. conclusions In the surfactant-depleted lung the activation of leukocytes was attenuated by HFO. Reduced inflammatory response correlated with decreased impairment of oxygenation. HFO may reduce lung injury via the attenuation of