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Báo cáo y học: "Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors | Available online http respiratory-research.eom content 2 3 145 Review Acute oxygen sensing diverse but convergent mechanisms in airway and arterial chemoreceptors Chris Peers and Paul J Kemp University of Leeds Leeds UK Correspondence Chris Peers Academic Unit of Cardiovascular Medicine Worsley Building University of Leeds Leeds LS2 9JT UK. Tel 44 113 233 4174 fax 44 113 233 4803 e-mail c.s.peers@leeds.ac.uk Received 20 February 2001 Revisions requested 27 February 2001 Revisions received 28 February 2001 Accepted 1 March 2001 Published 22 March 2001 Respir Res 2001 2 145-149 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Airway neuroepithelial bodies sense changes in inspired O2 whereas arterial O2 levels are monitored primarily by the carotid body. Both respond to hypoxia by initiating corrective cardiorespiratory reflexes thereby optimising gas exchange in the face of a potentially deleterious O2 supply. One unifying theme underpinning chemotransduction in these tissues is K channel inhibition. However the transduction components from O2 sensor to K channel display considerable tissue specificity yet result in analogous end points. Here we highlight how emerging data are contributing to a more complete understanding of O2 chemosensing at the molecular level. Keywords carotid body chemoreceptor hypoxia neuroepithelial body O2 sensing Introduction Aerobic metabolism requires an adequate supply of O2 and rapid adaptation to changes in the partial pressures of inspired atmospheric gases is crucial to survival. During episodes of compromised O2 availability numerous chemosensory systems acting in concert rapidly modulate pulmonary ventilation and perfusion to optimise the supply of O2 from alveolus to metabolising tissues. This review focuses on two key systems involved in this homeostatic response the carotid bodies CBs and neuroepithelial bodies NEBs representative chemoreceptors of the arterial circulation and the airway respectively 1