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Báo cáo y học: " Leukocyte adhesion and recruitment, and alpha-1"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Leukocyte adhesion and recruitment, and alpha-1. | Available online http respiratory-research.eom content 2 5 E004 Meeting report Leukocyte adhesion and recruitment and alpha-1-antitrypsin deficiency a report from ATS 2001 May 18-23 San Francisco Ian Woolhouse Department of Respiratory Medicine Queen Elizabeth Hospital Birmingham UK Correspondence Dr Ian Woolhouse MBBS MRCP Department of Respiratory Medicine Queen Elizabeth Hospital Birmingham UK. Tel 44 0 121 4147046 fax 44 0 121 6272012 e-mail ian.woolhouse@which.net Received 11 June 2001 Accepted 18 June 2001 Published 3 July 2001 Respir Res 2001 2 E004 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract The program at this year s American Thoracic Society international conference included over 300 scientific and clinical symposia. In this report I have reviewed the data presented on two important areas of lung inflammation namely leukocyte recruitment and alpha-1-antitrypsin deficiency. Highlights included work from a number of groups identifying the contribution of specific leukocyte adhesion molecules CD18 CD11a and vascular cell adhesion molecule-1 which varied according to the site and nature of the initial inflammatory stimulus. In addition work was presented examining the contribution of various chemoattractants to the process of leukocyte recruitment in chronic obstructive pulmonary disease with leukotriene B4 in particular appearing to play a major role. In alpha-1 -antitrypsin deficiency other molecules may also be important and work was presented demonstrating the pro-inflammatory potential of alpha-1-antitrypsin polymers in the lungs of these patients. These advances in the understanding of the basic mechanisms of inflammation will in the future allow the development of novel anti-inflammatory therapies for a variety of lung diseases. Keywords alpha-1-antitrypsin chronic obstructive pulmonary disease leukocyte leukocyte adhesion molecule 0 g o GT Introduction The American Thoracic Society international conference is the .