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Báo cáo y học: "The use of non-bronchoscopic brushings to study the paediatric airway"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:The use of non-bronchoscopic brushings to study the paediatric airway. | Respiratory Research BioMed Central Research Open Access The use of non-bronchoscopic brushings to study the paediatric airway Catherine Lane1 Scott Burgess1 2 Anthony Kicic1 Darryl Knight3 and Stephen Stick 1 2 Address 1School of Paediatrics and Child Health University of Western Australia Nedlands 6009 Western Australia Australia 2Department of Respiratory Medicine Princess Margaret Hospital for Children Perth 6001 Western Australia Australia and 3Department of Pharmacology and Therapeutics University of British Columbia Vancouver V6Z 1Y6 British Columbia Canada Email Catherine Lane - catherinel@ichr.uwa.edu.au Scott Burgess - sburgess@mater.org.au Anthony Kicic - anthonyk@ichr.uwa.edu.au Darryl Knight - dknight@mrl.ubc.ca Stephen Stick - Stephen.Stick@health.wa.gov.au Corresponding author Published 08 June 2005 Received 02 February 2005 Respiratory Research 2005 6 53 doi 10.1186 1465-9921 -6-53 Accepted 08 June 2005 This article is available from http respiratory-research.cOm content 6 1 53 2005 Lane et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The use of cytology brushes for the purpose of obtaining respiratory cells from adults for clinical and research purposes is well established. However the safety and utility of non-bronchoscopic brushings to study the paediatric airway has not been assessed. The purpose of this study was to assess the practicality of using non-bronchoscopic brushing to sample epithelial cells from children for investigation of epithelial function in health and disease using a wide range of molecular and cellular techniques. Methods Non-bronchoscopic brushing was investigated in a non-selected cohort of healthy and mildly asthmatic children presenting for surgery .