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Báo cáo y học: "Induction of p38- and gC1qR-dependent IL-8 expression in pulmonary fibroblasts by soluble hepatitis C core protein"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Induction of p38- and gC1qR-dependent IL-8 expression in pulmonary fibroblasts by soluble hepatitis C core protein. | Respiratory Research BioMed Central Research Open Access Induction of p38- and gCIqR-dependent IL-8 expression in pulmonary fibroblasts by soluble hepatitis C core protein Jonathan P Moorman 1 2 S Matthew Fitzgerald1 Deborah C Prayther1 Steven A Lee1 David S Chi1 and Guha Krishnaswamy1 2 Address Department of Internal Medicine James H. Quillen College of Medicine East Tennessee State University Johnson City TN USA and 2Medical Service James H. Quillen VAMC Johnson City TN USA Email Jonathan P Moorman - moorman@mail.etsu.edu S Matthew Fitzgerald - mattfitzgerald@aol.com Deborah C Prayther - prayther@mail.etsu.edu Steven A Lee - leesa@mail.etsu.edu David S Chi - chi@mail.etsu.edu Guha Krishnaswamy - krishnas@mail.etsu.edu Corresponding author Published 15 September 2005 Received 08 April 2005 Respiratory Research 2005 6 105 doi 10.1186 1465-9921-6-105 Accepted I5 September 2005 This article is available from http respiratory-research.cOm content 6 1 105 2005 Moorman et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recent studies suggest that HCV infection is associated with progressive declines in pulmonary function in patients with underlying pulmonary diseases such as asthma and chronic obstructive pulmonary disease. Few molecular studies have addressed the inflammatory aspects of HCV-associated pulmonary disease. Because IL-8 plays a fundamental role in reactive airway diseases we examined IL-8 signaling in normal human lung fibroblasts NHLF in response to the HCV nucleocapsid core protein a viral antigen shown to modulate intracellular signaling pathways involved in cell proliferation apoptosis and inflammation. Methods NHLF were treated with HCV core protein and assayed for IL-8 expression .