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Báo cáo y học: "The International Sepsis Forum’s controversies in sepsis: how will sepsis be treated in 2051"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: The International Sepsis Forum’s controversies in sepsis: how will sepsis be treated in 2051? | Available online http ccforum.eom content 6 6 465 Commentary The International Sepsis Forum s controversies in sepsis how will sepsis be treated in 2051 John C Marshall Professor of Surgery University of Toronto General and Critical Care Surgery Toronto General Hospital Toronto Ontario Canada Correspondence John C Marshall John.Marshall@uhn.on.ca Published online 17 July 2002 Critical Care 2002 6 465-467 DOI 10.1186 cc1539 This article is online at http ccforum.com content 6 6 465 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X This article is based on a presentation at the 31st Annual Congress of the Society of Critical Care Medicine SCCM San Diego California USA 26-30 January 2002. The presentation was supported by the International Sepsis Forum ISF . Abstract Sepsis the life-threatening illness that arises from innate immunity to overwhelming infection is treated symptomatically at the start of the 21st century. Looking ahead 50 years one can perhaps foresee profound changes in the way we manage this disorder. A shift from a focus on eradicating microorganisms as universally inimical to one on supporting optimal host-microbial homeostasis will have a profound impact on how we treat infection and will relegate antibiotics to a small adjuvant role. Probiotic therapy may well be as important as antibiotic therapy. Resuscitation strategies will support microvascular flow rather than systemic pressure. Rapid genetic profiling will permit pre-emptive gene therapy for some and titration of specific therapies directed against fundamental intracellular processes in others. We will treat diseases not syndromes and guide therapy by molecular staging. A fanciful victim of sepsis in 2051 illustrates how future treatments might transform sepsis from a prolonged and morbid illness to a rapidly reversed acute disease. Keywords host-microbial interactions infection polymorphisms probiotics It is a sobering experience to be faced with a blank page and to be .