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Báo cáo khoa học: "Intravenous colistin in the treatment of sepsis from multiresistant Gram-negative bacilli in critically ill patient"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Intravenous colistin in the treatment of sepsis from multiresistant Gram-negative bacilli in critically ill patients. | Critical Care October 2003 Vol 7 No 5 Markou et al. Research Open Access Intravenous colistin in the treatment of sepsis from multiresistant Gram-negative bacilli in critically ill patients Nikolaos Markou1 Haralampos Apostolakos2 Christiana Koumoudiou1 Maria Athanasiou1 Alexandra Koutsoukou3 Ioannis Alamanos1 and Leonidas Gregorakos1 intensive Care Unit B Athens Trauma Hospital KAT Athens Greece 2Head of Department Intensive Care Unit B Athens Trauma Hospital KAT Athens Greece 3Microbiology Laboratory Athens Trauma Hospital KAT Athens Greece Correspondence Nikolaos Markou nikolaos_markou@hotmail.com Received 1 May 2003 Revisions requested 9 June 2003 Revisions received 7 July 2003 Accepted 8 July 2003 Published 28 July 2003 Critical Care 2003 7 R78-R83 DOI 10.1186 cc2358 This article is online at http ccforum.com content 7 5 R78 2003 Markou et al. licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Introduction The increasing prevalence of multiresistant Gram-negative strains in intensive care units ICUs has recently rekindled interest in colistin a bactericidal antibiotic that was used in the 1960s for treatment of infections caused by Gram-negative bacilli. We conducted the present observational study to evaluate the efficacy of intravenous colistin in the treatment of critically ill patients with sepsis caused by Gram-negative bacilli resistant to all other antibiotics. Patients and method Critically ill patients with sepsis caused by Gram-negative bacilli resistant to all antibiotics with the exception of colistin were treated in the six-bed ICU of a trauma hospital. Diagnosis of infection was based on clinical data and isolation of bacteria and the bacteria were tested with respect to their susceptibility to colistin. Clinical .