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Báo cáo khoa học: " A Lung and 'end organ' injury due to mechanical ventilation in animals: comparison between the prone and supine positions"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A Lung and 'end organ' injury due to mechanical ventilation in animals: comparison between the prone and supine positions. | Available online http ccforum.eom content 10 1 R38 Research Lung and end organ injury due to mechanical ventilation in animals comparison between the prone and supine positions George Nakos1 Anna Batistatou2 Eftychia Galiatsou1 Eleonora Konstanti1 Vassilios Koulouras1 Panayotis Kanavaros3 Apostolos Doulis1 Athanassios Kitsakos1 Angeliki Karachaliou1 Marilena E Lekka4 and Maria Bai2 Open Access Department of Intensive Care Unit University Hospital of loannina Greece department of Pathology University of loannina Greece department of Anatomy-Histology-Embryology University of loannina Greece department of Chemistry University of loannina Greece Corresponding author George Nakos gnakos@cc.uoi.gr Received 2 Nov 2005 Revisions requested 8 Dec 2005 Revisions received 25 Jan 2006 Accepted 3 Feb 2006 Published 28 Feb 2006 Critical Care 2006 10 R38 doi 10.1186 cc4840 This article is online at http ccforum.com content 10 1 R38 2006 Nakos et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Use of the prone position in patients with acute lung injury improves their oxygenation. Most of these patients die from multisystem organ failure and not from hypoxia however. Moreover there is some evidence that the organ failure is caused by increased cell apoptosis. In the present study we therefore examined whether the position of the patients affects histological changes and apoptosis in the lung and end organs including the brain heart diaphragm liver kidneys and small intestine. Methods Ten mechanically ventilated sheep with a tidal volume of 15 ml kg body weight were studied for 90 minutes. Five sheep were placed in the supine position and five sheep were placed in the prone position during the experiment. Lung .