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Báo cáo y học: " Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: " Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase. | Retrovirology BioMed Central Research Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase Mohd J Dar1 3 Blandine Monel 1 Lavanya Krishnan 1 Ming-Chieh Shun1 Francesca Di Nunzio1 Dag E Helland2 and Alan Engelman 1 Address Department of Cancer Immunology and AIDS Dana-Farber Cancer Institute 44 Binney Street Boston MA USA 2Molecular Biology Institute University of Bergen N-5020 Bergen Norway and 3Current Address University of Pittsburgh School of Medicine S-427 BST 200 Lothrop Street Pittsburgh PA 15213 USA Email Mohd J Dar - mjd82 @pitt.edu Blandine Monel - Blandine_Monel@dfci.harvard.edu Lavanya Krishnan - lavanya_krishnan@dfci.harvard.edu Ming-Chieh Shun - michelle_shun@dfci.harvard.edu Francesca Di Nunzio - Francesca_DiNunzio@dfci.harvard.edu Dag E Helland - Helland@mbi.uib.no Alan Engelman - alan_engelman@dfci.harvard.edu Corresponding author fEqual contributors Open Access Published 19 October 2009 Received 15 July 2009 Retrovirology 2009 6 94 doi 10.1186 1742-4690-6-94 Accepted 19 October 2009 This article is available from http www.retrovirology.com content 6 1 94 2009 Dar et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The 18 residue tail abutting the SH3 fold that comprises the heart of the C-terminal domain is the only part of HIV-1 integrase yet to be visualized by structural biology. To ascertain the role of the tail region in integrase function and HIV-1 replication a set of deletion mutants that successively lacked three amino acids was constructed and analyzed in a variety of biochemical and virus infection assays. HIV-1 2 chimers which harbored the analogous .