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Báo cáo y học: "Sedation in the intensive care unit with remifentanil/propofol versus midazolam/fentanyl: a randomised, open-label, pharmacoeconomic trial"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Sedation in the intensive care unit with remifentanil/propofol versus midazolam/fentanyl: a randomised, open-label, pharmacoeconomic trial. | Available online http ccforum.eom content 10 3 R91 Research Sedation in the intensive care unit with remifentanil propofol versus midazolam fentanyl a randomised open-label pharmacoeconomic trial Bernd Muellejans1 Thomas Matthey1 Joachim Scholpp2 and Markus Schill2 1 Department of Anaesthesiology and Intensive Care Medicine Heart Centre Mecklenburg-Vorpommern Germany 2Medical Department GlaxoSmithKline Munich Germany Corresponding author Bernd Muellejans dr.muellejans@drguth.de Received 26 Jan 2006 Revisions requested 14 Feb 2006 Revisions received 8 Mar 2006 Accepted 8 May 2006 Published 15 Jun 2006 Critical Care 2006 10 R91 doi 10.1186 cc4939 This article is online at http ccforum.com content 10 3 R91 2006 Muellejans et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Introduction Remifentanil is an opioid with a unique pharmacokinetic profile. Its organ-independent elimination and short context-sensitive half time of 3 to 4 minutes lead to a highly predictable offset of action. We tested the hypothesis that with an analgesia-based sedation regimen with remifentanil and propofol patients after cardiac surgery reach predefined criteria for discharge from the intensive care unit ICU sooner resulting in shorter duration of time spent in the ICU compared to a conventional regimen consisting of midazolam and fentanyl. In addition the two regimens were compared regarding their costs. Methods In this prospective open-label randomised singlecentre study a total of 80 patients 18 to 75 years old who had undergone cardiac surgery were postoperatively assigned to one of two treatment regimens for sedation in the ICU for 12 to 72 hours. Patients in the remifentanil propofol group received remifentanil 6- max. 60 pg .