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Báo cáo y học: "Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure. | Available online http ccforum.eom content 10 4 R108 Research Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure Wim Laleman1 Alexander Wilmer2 Pieter Evenepoel3 Ingrid Vander Elst1 Marcel Zeegers1 Zahur Zaman4 Chris Verslype1 Johan Fevery1 and Frederik Nevens1 Open Access Department of Hepatology University Hospital Gasthuisberg KU Leuven Belgium 2Department of Medical Intensive Care University Hospital Gasthuisberg KU Leuven Belgium 3Department of Nephrology University Hospital Gasthuisberg KU Leuven Belgium 4Department of Laboratory Medicine University Hospital Gasthuisberg KU Leuven Belgium Corresponding author Frederik Nevens frederik.nevens@uz.kuleuven.ac.be Received 25 May 2006 Revisions requested 26 Jun 2006 Revisions received 29 Jun 2006 Accepted 10 Jul 2006 Published 19 Jul 2006 Critical Care 2006 10 R108 doi 10.1186 cc4985 This article is online at http ccforum.com content 10 4 R1 08 2006 Nevens et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Patients with acute-on-chronic liver failure show an aggravated hyperdynamic circulation. We evaluated in a controlled manner potential changes in systemic haemodynamics induced by the molecular adsorbent recirculating system MARS and the Prometheus system liver detoxification devices in a group of patients with acute-on-chronic liver failure. Methods Eighteen patients 51.2 2.3 years old Child-Pugh score 12.5 0.2 Maddrey score 63.1 5.0 hepatic venous pressure gradient 17.6 0.9 mmHg with biopsy-proven alcoholic cirrhosis and superimposed alcoholic hepatitis were either treated with standard medical therapy SMT .