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Báo cáo khoa học: "What does high NT-proBNP mean in septic shock patients? A part of the puzzle"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: What does high NT-proBNP mean in septic shock patients? A part of the puzzle. | Available online http ccforum.eom content 11 2 122 Commentary What does high NT-proBNP mean in septic shock patients A part of the puzzle Antoine Roch Service de Réanimation Médicale Hôpitaux Sud boulevard Sainte Marguerite 13274 Marseille cedex 9 France Corresponding author Antoine Roch antoine.roch@ap-hm.f Published 13 April 2007 This article is online at http ccforum.com content 11 2 122 2007 BioMed Central Ltd Critical Care 2007 11 122 doi 10.1186 cc5728 See related research by Mokart et al. http ccforum.com content 11 2 R37 Abstract B-type natriuretic peptide BNP and amino-terminal pro-BNP NT-proBNP plasma levels are commonly high at the early phase of septic shock and have been suggested to be prognostic markers for this condition. It is uncertain however whether this increase reflects sepsis related cardiac dysfunction. In a recent issue of Critical Care Mokart and coworkers showed the accuracy of NT-proBNP in predicting intensive care unit mortality in cancer patients with septic shock which could help in identifying high risk cancer patients. Results from repeated transthoracic echocardiographs show that NT-proBNP on day 2 after admission was higher in patients presenting with cardiac dysfunction whereas NT-proBNP on day 1 did not predict cardiac dysfunction. These data suggest that after an initial overexpression of NT-proBNP in all septic patients patients with cardiac dysfunction will present persistent high levels of NT-proBNP. In this issue of Critical Care Mokart and coworkers 1 report the results of a prospective cohort study evaluating plasma amino-terminal pro-B-type natriuretic peptide NT-proBNP as a marker of prognosis and cardiac dysfunction in cancer patients with septic shock. They included 51 patients mainly with hematological malignancies. By univariate analysis Logistic Organ Dysfunction score early NT-proBNP level and recent hematopoietic stem-cell transplantation were associated with intensive care unit ICU mortality. In a multivariate .