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Báo cáo y học: "APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA. | Retrovirology BioMed Central Research APOBEC3G induces a hypermutation gradient purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA intermediate in cellular viral RNA and low in virion RNA Rebecca A Russell1 Michael D Moore2 Wei-Shau Hu2 and Vinay K Pathak 1 Open Access Address 1Viral Mutation Section HIV Drug Resistance Program Center for Cancer Research National Cancer Institute at Frederick Frederick Maryland 21702 USA and 2Viral Recombination Section HIV Drug Resistance Program Center for Cancer Research National Cancer Institute at Frederick Frederick Maryland 21702 USA Email Rebecca A Russell - rebecca.russell@path.ox.ac.uk Michael D Moore - kenny.moore@path.ox.ac.uk Wei-Shau Hu - whu@ncifcrf.gov Vinay K Pathak - vpathak@ncifcrf.gov Corresponding author Published 13 February 2009 Received 23 December 2008 Accepted 13 February 2009 Retrovirology 2009 6 16 doi l0.ll86 l742-4690-6-l6 This article is available from http www.retrovirology.cOm content 6 l l6 2009 Russell et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Naturally occurring Vif variants that are unable to inhibit the host restriction factor APOBEC3G A3G have been isolated from infected individuals. A3G can potentially induce G-to-A hypermutation in these viruses and hypermutation could contribute to genetic variation in HIV-l populations through recombination between hypermutant and wild-type genomes. Thus hypermutation could contribute to the generation of immune escape and drug resistant variants but the genetic contribution of hypermutation to the viral evolutionary potential is poorly