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Báo cáo y học: "Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression. | Retrovirology BioMed Central Research Primary T-cells from human CD4 CCR5-transgenic rats support all early steps of HIV-1 replication including integration but display impaired viral gene expression Christine Goffinet1 Nico Michel1 Ina Allespach1 Hanna-Mari Tervo1 Volker Hermann1 Hans-Georg Krausslich1 Warner C Greene2 3 and Oliver T Keppler 1 Open Access Address Department of Virology University of Heidelberg Heidelberg Germany 2Gladstone Institute of Virology and Immunology San Francisco USA and 3Departments of Medicine and Microbiology and Immunology University of California San Francisco San Francisco USA Email Christine Goffinet - Christine.goffinet@med.uni-heidelberg.de Nico Michel - nico.michel@med.uni-heidelberg.de Ina Allespach - ina.allespach@med.uni-heidelberg.de Hanna-Mari Tervo - hanna-mari.tervo@med.uni-heidelberg.de Volker Hermann - Volker.Hermann@web.de Hans-Georg Krausslich - hans-georg.kraeusslich@med.uni-heidelberg.de Warner C Greene - wgreene@gladstone.ucsf.edu Oliver T Keppler - oliver_keppler@med.uni-heidelberg.de Corresponding author Published 26 July 2007 Received 25 April 2007 Retrovirology 2007 4 53 doi 10.1186 1742-4690-4-53 Accepted 26 July 2007 This article is available from http www.retrovirology.cOm content 4 1 53 2007 Goffinet et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In vivo studies on HIV-I pathogenesis and testing of antiviral strategies have been hampered by the lack of an immunocompetent small animal model that is highly susceptible to HIV-I infection. Since native rodents are non-permissive we developed transgenic rats that selectively express the HIV-I receptor complex hCD4 and hCCR5 on relevant target cells. These animals display a transient low-level