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Báo cáo y học: "Both TRIM5α and TRIMCyp have only weak antiviral activity in canine D17 cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Both TRIM5α and TRIMCyp have only weak antiviral activity in canine D17 cells. | BioMed Central Retrovirology Research Open Access Both TRIM5a and TRIMCyp have only weak antiviral activity in canine D17 cells Julie Bérubé Amélie Bouchard and Lionel Berthoux Address Laboratory of Retrovirology GRBCM University of Québec Trois-Rivières QC G9A 5H7 Canada Email Julie Bérubé - julie.berube1@uqtr.ca Amélie Bouchard - amelie.bouchard1@uqtr.ca Lionel Berthoux - lionel.berthoux@uqtr.ca Corresponding author Published 24 September 2007 Received 19 June 2007 Accepted 24 September 2007 Retrovirology 2007 4 68 doi 10.1186 1742-4690-4-68 This article is available from http www.retrovirology.cOm content 4 1 68 2007 Bérubé et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background TRIM5a which is expressed in most primates and the related TRIMCyp which has been found in one of the New World monkey species are antiviral proteins of the TRIM5 family that are able to intercept incoming retroviruses early after their entry into cells. The mechanism of action has been partially elucidated for TRIM5a which seems to promote premature decapsidation of the restricted retroviruses. In addition through its N-terminal RING domain TRIM5a may sensitize retroviruses to proteasome-mediated degradation. TRIM5a-mediated restriction requires a physical interaction with the capsid protein of targeted retroviruses. It is unclear whether other cellular proteins are involved in the inhibition mediated by TRIM5a and TRIMCyp. A previous report suggested that the inhibition of HIV-1 by the rhesus macaque orthologue of TRIM5a was inefficient in the D17a canine cell line suggesting that the cellular environment was important for the restriction mechanism. Here we investigated further the behavior of TRIM5a and TRIMCyp in the D17 .