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Báo cáo y học: " Induction of the HIV-1 Tat co-factor cyclin T1 during monocyte differentiation is required for the regulated expression of a large portion of cellular mRNAs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Induction of the HIV-1 Tat co-factor cyclin T1 during monocyte differentiation is required for the regulated expression of a large portion of cellular mRNAs. | Retrovirology BioMed Central Research Induction of the HIV-1 Tat co-factor cyclin T1 during monocyte differentiation is required for the regulated expression of a large portion of cellular mRNAs Wendong Yu1 Yan Wang1 Chad A Shaw2 Xiao-Feng Qin3 and Andrew P Rice 1 Open Access Address Department of Molecular Virology and Microbiology Baylor College of Medicine Houston Texas 77030 USA 2Department of Human and Molecular Genetics Baylor College of Medicine Houston Texas USA and 3Center for Cancer Immunology Research Department of Immunology The University of Texas M.D. Anderson Cancer Center Houston Texas USA Email Wendong Yu - wy132177@bcm.tmc.edu YanWang-yw135452@bcm.tmc.edu Chad A Shaw - cashaw@bcm.tmc.edu Xiao- Feng Qin - fqin@mdanderson.org Andrew P Rice - arice@bcm.tmc.edu Corresponding author Published 09 June 2006 Received 27 April 2006 Retrovirology 2006 3 32 doi 10.1186 1742-4690-3-32 Accepted 09 June 2006 This article is available from http www.retrovirology.cOm content 3 1 32 2006 Yu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background P-TEFb a general RNA polymerase II elongation factor is composed of CDK9 cyclin-dependent kinase 9 as a catalytic unit and either cyclin T1 T2 or K as a regulatory subunit. The cyclin TI P-TEFb complex is targeted by HIV to mediate Tat transactivation. Cyclin Tl protein expression is induced during early macrophage differentiation suggesting a role in regulation of mRNA expression during the differentiation process. To study the functional significance of cyclin T1 induction during differentiation we utilized the human Mono Mac 6 MM6 monocytic cell line. Results We found that .