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Báo cáo y học: " The retrovirus RNA trafficking granule: from birth to maturity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:The retrovirus RNA trafficking granule: from birth to maturity | Retrovirology BioMed Central Review Open Access The retrovirus RNA trafficking granule from birth to maturity Alan W Cochrane1 MarkT McNally2 and Andrew J Mouland 3 Address Department of Medical Genetics and Microbiology University of Toronto 1 King s College Circle Toronto Ontario M5S 1A8 Canada 2Department of Microbiology and Molecular Genetics Medical College of Wisconsin Milwaukee WI 53226 USA and 3HIV-1 RNA Trafficking Laboratory Lady Davis Institute for Medical Research-Sir Mortimer B. Davis Jewish General Hospital and McGill University 3755 Côte-Ste-Catherine Road H3T 1E2 Canada Email Alan W Cochrane - alan.cochrane@utoronto.ca MarkT McNally - mtm@mcw.edu Andrew J Mouland - andrew.mouland@mcgill.ca Corresponding author Published 17 March 2006 Received 02 November 2005 Accepted 17 March 2006 Retrovirology 2006 3 18 doi l0.ll86 l 742-4690-3-18 This article is available from http www.retrovirology.cOm content 3 1 18 2006 Cochrane et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Post-transcriptional events in the life of an RNA including RNA processing transport translation and metabolism are characterized by the regulated assembly of multiple ribonucleoprotein RNP complexes. At each of these steps there is the engagement and disengagement of RNA-binding proteins until the RNA reaches its final destination. For retroviral genomic RNA the final destination is the capsid. Numerous studies have provided crucial information about these processes and serve as the basis for studies on the intracellular fate of retroviral RNA. Retroviral RNAs are like cellular mRNAs but their processing is more tightly regulated by multiple c s-acting sequences and the activities of many trons-acting proteins. This review .