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Báo cáo y học: " A phase 1 trial of nebulised heparin in acute lung injury"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: A phase 1 trial of nebulised heparin in acute lung injury. | Available online http ccforum.eom content 1 2 3 R64 Research A phase 1 trial of nebulised heparin in acute lung injury Barry Dixon1 John D Santamaria1 and Duncan J Campbell2 Open Access Department of Intensive Care St Vincent s Hospital 41 Victoria Parade Melbourne 3065 Australia 2StVincent s Institute of Medical Research 41 Victoria Parade Melbourne 3065 Australia Corresponding author Barry Dixon barry.dixon@svhm.org.au Received 12 Feb 2008 Revisions requested 20 Mar 2008 Revisions received 2 Apr 2008 Accepted 6 May 2008 Published 6 May 2008 Critical Care 2008 12 R64 doi 10.1186 cc6894 This article is online at http ccforum.com content 12 3 R64 2008 Dixon et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Animal studies of acute lung injury ALI suggest nebulised heparin may limit damage from fibrin deposition in the alveolar space and microcirculation. No human studies have been undertaken to date. We assessed the feasibility safety and potential anticoagulant effects of administration of nebulised heparin to patients with ALI. Methods An open label phase 1 trial of four escalating doses of nebulised heparin was performed. A total of 16 ventilated patients with ALI were studied. The first group was administered a total of 50 000 U day the second group 100 000 U day the third group 200 000 U day and the fourth group 400 000 U day. Assessments of lung function included the PaO2 FiO2 ratio lung compliance and the alveolar dead space fraction. Monitoring of anticoagulation included the activated partial thromboplastin time APTT and the thrombin clotting time. Bronchoalveolar lavage fluid was collected and the prothrombin fragment and tissue plasminogen activator levels were assessed. Analysis of .

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