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Báo cáo y học: "Sepsis therapy: what’s the best for the mitochondria"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Sepsis therapy: what’s the best for the mitochondria? | Available online http ccforum.eom content 12 4 171 Commentary Sepsis therapy what s the best for the mitochondria Florian Wagner Peter Radermacher Michael Georgieff and Enrico Calzia Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung Universitatsklinik fur Anasthesiologie Universitat Ulm ParkstraBe 89073 Ulm Germany Corresponding author Enrico Calzia enrico.calzia@uni-ulm.de Published 6 August 2008 This article is online at http ccforum.com content 12 4 171 2008 BioMed Central Ltd Critical Care 2008 12 171 doi 10.1186 cc6964 See related research by Regueira et al. http ccforum.com content 12 4 R88 Abstract It is suspected that mitochondrial dysfunction is a major cause of organ failure in sepsis and septic shock. A study presented in this issue of Critical Care revealed that liver mitochondria from pigs treated with norepinephrine during endotoxaemia exhibit greater in vitro respiratory activity. The investigators provide an elegant demonstration of how therapeutic interventions in sepsis may profoundly influence mitochondrial respiration but many aspects of mitochondrial function in sepsis remain to be clarified. In this issue of Critical Care Regueira and colleagues 1 report an interesting study of the effects of norepinephrine on mitochondrial respiration in endotoxaemic rats it should be of particular interest to those involved in sepsis research. During the past decade failure of energy metabolism at the cellular level has emerged as one of the potentially most important pathophysiological aspects of sepsis 2 . Indeed the results of a number of experimental and human studies appear to confirm that mitochondrial function is severely compromised in sepsis 2-5 in a phenomenon termed cytopathic hypoxia 6 . Nevertheless there probably remain more questions than answers in this fairly novel aspect of septic disease and -from a clinical point of view - the fundamental query is already apparent. If sepsis is a mitochondrial disease then should we .