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Báo cáo y học: "Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis. | Available online http ccforum.eom content 1 2 5 R128 Research Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis Stefan U Weber1 Jens-Christian Schewe1 Lutz E Lehmann1 Stefan Muller1 Malte Book1 Sven Klaschik2 Andreas Hoeft1 and Frank Stuber3 Open Access 1 Department of Anesthesiology and Intensive Care Medicine University Bonn Medical Center Sigmund-Freud-StraBe 25 53129 Bonn Germany 2Center for Biologics Evaluation and Research CBER Food and Drug Administration 1401 Rockville Pike Suite 200N Rockville MD 20852-1448 USA 3Department of Anaesthesiology and Pain Therapy University Hospital Bern Inselspital 3010 Bern Switzerland Contributed equally Corresponding author Stefan U Weber Stefan.weber@ukb.uni-bonn.de Received 19 Jun 2008 Revisions requested 14 Jul 2008 Revisions received 29 Aug 2008 Accepted 16 Oct 2008 Published 16 Oct 2008 Critical Care 2008 12 R128 doi 10.1186 cc7088 This article is online at http ccforum.com content 12 5 R1 28 2008 Weber et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction In transgenic animal models of sepsis members of the Bcl-2 family of proteins regulate lymphocyte apoptosis and survival of sepsis. This study investigates the gene regulation of pro-apoptotic and anti-apoptotic members of the Bcl-2 family of proteins in patients with early stage severe sepsis. Methods In this prospective case-control study patients were recruited from three intensive care units ICUs in a university hospital. Sixteen patients were enrolled when they fulfilled the criteria of severe sepsis. Ten critically ill but non-septic patients and 11 healthy volunteers served as controls. Blood samples were immediately obtained at inclusion. To confirm the .