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Báo cáo y học: "a comparison with reference values and the effect of positive end-expiratory pressure in intensive care unit patients with different lung condition"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: End-expiratory lung volume during mechanical ventilation: a comparison with reference values and the effect of positive end-expiratory pressure in intensive care unit patients with different lung conditions. | Available online http ccforum.eom content 1 2 6 R145 Research End-expiratory lung volume during mechanical ventilation a comparison with reference values and the effect of positive end-expiratory pressure in intensive care unit patients with different lung conditions Ido G Bikker Jasper van Bommel Dinis Reis Miranda Jan Bakker and Diederik Gommers Department of Intensive Care Medicine Erasmus MC s Gravendijkwal 230 3015 CERotterdam The Netherlands Corresponding author Diederik Gommers d.gommers@erasmusmc.nl Received 25 Jun 2008 Revisions requested 31 Jul 2008 Revisions received 30 Oct 2008 Accepted 20 Nov 2008 Published 20 Nov 2008 Critical Care 2008 12 R145 doi 10.1186 cc7125 This article is online at http ccforum.com content 12 6 R1 45 2008 Bikker et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Functional residual capacity FRC reference values are obtained from spontaneous breathing patients and are measured in the sitting or standing position. During mechanical ventilation FRC is determined by the level of positive end-expiratory pressure PEEP and it is therefore better to speak of end-expiratory lung volume. Application of higher levels of PEEP leads to increased end-expiratory lung volume as a result of recruitment or further distention of already ventilated alveoli. The aim of this study was to measure end-expiratory lung volume in mechanically ventilated intensive care unit ICU patients with different types of lung pathology at different PEEP levels and to compare them with predicted sitting FRC values arterial oxygenation and compliance values. Methods End-expiratory lung volume measurements were performed at PEEP levels reduced sequentially 15 10 and then 5 cmH2O in 45 .