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Báo cáo y học: "The effect of glutamine infusion on the inflammatory response and HSP70 during human experimental endotoxaemia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The effect of glutamine infusion on the inflammatory response and HSP70 during human experimental endotoxaemia. | Available online http ccforum.eom content 13 1 R7 Research The effect of glutamine infusion on the inflammatory response and HSP70 during human experimental endotoxaemia Anne Sofie Andreasen1 Theis Pedersen-Skovsgaard1 Ole Hartvig Mortensen1 Gerrit van Hall1 2 Pope Lloyd Moseley1 and Bente Klarlund Pedersen1 1The Centre of Inflammation and Metabolism Department of Infectious Diseases and Copenhagen Muscle Research Center Rigshospitalet Faculty of Health Sciences University of Copenhagen Blegdamsvej DK-2100 Copenhagen Denmark 2Department of Biomedical Sciences University of Copenhagen Tagensvej DK-2200 Copenhagen Denmark Contributed equally Corresponding author Anne Sofie Andreasen sofie_andreasen@msn.com Received 29 Oct 2008 Revisions requested 6 Dec 2008 Revisions received 19 Dec 2008 Accepted 27 Jan 2009 Published 27 Jan 2009 Critical Care 2009 13 R7 doi 10.1186 cc7696 This article is online at http ccforum.com content 13 1 R7 2009 Andreasen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Glutamine supplementation has beneficial effects on morbidity and mortality in critically ill patients possibly in part through an attenuation of the proinflammatory cytokine response and a stimulation of heat shock protein HSP 70. We infused either alanine-glutamine or saline during endotoxin challenge and measured plasma cytokines and HSP70 protein expression. Methods This crossover study conducted in eight healthy young men was double-blind randomized and placebo-controlled. It was performed on 2 trial days separated by a 4week washout period. The volunteers received an infusion of alanine-glutamine at a rate of 0.025 g kg body weight X hour or saline for 10 hours. After 2 hours an intravenous