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Báo cáo y học: "Sedation improves early outcome in severely septic Sprague Dawley rats"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Sedation improves early outcome in severely septic Sprague Dawley rats. | Available online http ccforum.eom content 13 4 R136 Research Sedation improves early outcome in severely septic Sprague Dawley rats Hong Qiao1 Robert D Sanders2 Daqing Ma2 Xinmin Wu1 and Mervyn Maze2 Department of Anesthesiology First Hospital Peking University No. 8 Xishiku St. Beijing 100034 PR China department of Anaesthetics Intensive Care and Pain Medicine Imperial College London Chelsea Westminster Hospital 369 Fulham Rd London SW10 9NH UK Corresponding author Robert D Sanders robert.sanders@imperial.ac.ukXinmin Wu xmwu2784@hotmail.com Received 20 May 2009 Revisions requested 7 Jul 2009 Revisions received 14 Jul 2009 Accepted 19 Aug 2009 Published 19 Aug 2009 Critical Care 2009 13 R136 doi 10.1186 cc8012 This article is online at http ccforum.com content 13 4 R136 2009 Qiao et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Sepsis a systemic inflammatory response to infective etiologies has a high mortality rate that is linked both to excess cytokine activity and apoptosis of critical immune cells. Dexmedetomidine has recently been shown to improve outcome in a septic cohort of patients when compared to patients randomized to a benzodiazepine-based sedative regimen. We sought to compare the effects of dexmedetomidine and midazolam at equi-sedative doses on inflammation and apoptosis in an animal model of severe sepsis. Methods After central venous access Sprague Dawley rats underwent cecal ligation and intestinal puncture CLIP with an 18 G needle without antibiotic cover and received either saline or an infusion of comparable volume of saline containing midazolam 0.6 mg.kg-1.h-1 or dexmedetomidine 5 ug.kg-1.h-1 for 8 hours. Following baseline measurements and CLIP blood was .