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Báo cáo y học: "Effect of fluid resuscitation on mortality and organ function in experimental sepsis model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of fluid resuscitation on mortality and organ function in experimental sepsis models. | Available online http ccforum.eom content 13 6 R186 Research Effect of fluid resuscitation on mortality and organ function in experimental sepsis models Sebastian Brandt1 Tomas Regueira2 Hendrik Bracht2 Francesca Porta2 Siamak Djafarzadeh2 Jukka Takala2 José Gorrasi2 Erika Borotto2 Vladimir Krejci1 Luzius B Hiltebrand1 Lukas E Bruegger3 Guido Beldi3 Ludwig Wilkens5 Philipp M Lepper2 Ulf Kessler4 and Stephan M Jakob2 1 Department of Anaesthesia and Pain Therapy Inselspital Bern University Hospital and University of Bern CH-3010 Bern Switzerland 2Department of Intensive Care Medicine Inselspital Bern University Hospital and University of Bern CH-3010 Bern Switzerland department of Visceral and Transplant Surgery Inselspital Bern University Hospital and University of Bern CH-3010 Bern Switzerland 4Department of Pediatric Surgery Inselspital Bern University Hospital and University of Bern CH-3010 Bern Switzerl institute of Pathology University of Bern Murtenstrasse 31 CH-3010 Bern Switzerland Contributed equally Corresponding author Stephan M Jakob StephanJakob@insel.ch Received 31 Jul 2009 Revisions requested 21 Sep 2009 Revisions received 12 Oct 2009 Accepted 23 Nov 2009 Published 23 Nov 2009 Critical Care 2009 13 R186 doi 10.1186 cc8179 This article is online at http ccforum.com content 13 6 R1 86 2009 Brandt et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Several recent studies have shown that a positive fluid balance in critical illness is associated with worse outcome. We tested the effects of moderate vs. high-volume resuscitation strategies on mortality systemic and regional blood flows mitochondrial respiration and organ function in two experimental sepsis models. Methods 48 .