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Báo cáo y học: "Effect of Hyperbaric Oxygen Therapy on whole blood cyanide concentrations in carbon monoxide intoxicated patients from fire accident"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of Hyperbaric Oxygen Therapy on whole blood cyanide concentrations in carbon monoxide intoxicated patients from fire accident | Lawson-Smith et al. Scandinavian Journal of Trauma Resuscitation and Emergency Medicine 2010 18 32 http www.sjtrem.eom content 18 1 32 SCANDINAVIAN JOURNAL OF Et emergency medicine ORIGINAL RESEARCH Open Access Effect of Hyperbaric Oxygen Therapy on whole blood cyanide concentrations in carbon monoxide intoxicated patients from fire accidents Pia Lawson-Smith 1 Erik C Jansen 2 Linda Hilsted 3 and Ole Hyldegaard 1 2 Abstract Background Hydrogen cyanide HCN and carbon monoxide CO may be important components of smoke from fire accidents. Accordingly patients admitted to hospital from fire accidents may have been exposed to both HCN and CO. Cyanide CN intoxication results in cytotoxic hypoxia leading to organ dysfunction and possibly death. While several reports support the use of hyperbaric oxygen therapy HBO for the treatment of severe CO poisoning limited data exist on the effect of HBO during CN poisoning. HBO increases the elimination rate of CO haemoglobin in proportion to the increased oxygen partial pressure and animal experiments have shown that in rats exposed to CN intoxication HBO can increase the concentration of CN in whole blood. Objective The purpose of the present study was to determine whole blood CN concentrations in fire victims before and after HBO treatment. Materials and methods The patients included were those admitted to the hospital because of CO intoxication either as fire victims with smoke inhalation injuries or from other exposures to CO. In thirty-seven of these patients we measured CN concentrations in blood samples using a Conway microdiffusion technique before and after HBO. The blood samples consisted of the remaining 2 mL from the arterial blood gas analysis. CN concentration in blood from fire victims was compared to 12 patients from non-fire accidents but otherwise also exposed to CO intoxication. Results The mean WB-CN concentration before patients received HBO did not differ significantly between the two groups of patients p 0.42