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Báo cáo y học: "High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis | Albayrak et al. Scandinavian Journal of Trauma Resuscitation and Emergency Medicine 2011 19 27 http www.sjtrem.eom content 19 1 27 SCANDINAVIAN JOURNAL OF a emergency medicine ORIGINAL RESEARCH Open Access High mobility group box protein-1 HMGB-1 as a new diagnostic marker in patients with acute appendicitis SL I I 7 Al 1 s r sl.z1A Al 1 s V S is2 h ỉ I I n m z-xt- 7 I I Is3 I -s n I r I 1z I is4 I I W I I I CA m I rx I I m s-75 D-ihr-iVX ì I n I rì m6 X I Yavuz AlbayraK Ayse AlbayraK MUndmmei CeliK Ibrahim GelinciK Ismail Demiryilmaz Kansan Yildirim ana Bunyami Ozogul7 Background The aim of this prospective study was therefore to evaluate the diagnostic value of preoperative serum High Mobility Group Box Protein-1 HMGB-1 levels in patients with Acute Appendicitis AA who show normal white blood cell count WBC counts. Method Our study was carried out from October 2010 through November 2010 and included 20 healthy control group participants and 60 patients who presented at the emergency department of Erzurum Training and Research Hospital in Turkey with acute abdominal pain complaints who were pathologically diagnosed with AA after laparotomy and who agreed to participate in the study. Results Of the 60 patients who underwent appendectomies 36 were male and 24 were female and of the healthy group 12 were male and 8 female. The age averages of the patients in Groups 1 2 and 3 were respectively 31.3 15.4 34.0 16.3 and 31.0 13.1 years. The WBC averages of Groups 1 2 and 3 were respectively 7.41 2.02 x109 L 15.71 2.85 x109 L and 8.51 1.84 x109 L . The HMGB-1 levels for Groups 1 healthy persons 2 AA patients with high WBC counts and 3 AA patients with normal WBC counts were respectively 21.71 11.36 37.28 13.37 and 36.5 17.73 ng ml. The average HMGB-1 level of the patients with AA was 36.92 15.43 ng ml while the average HMGB-1 value of the healthy group was 21.71 11.36 ng ml. Conclusion The significantly higher levels of HMGB-1 in AA patients compared to healthy persons .