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Báo cáo y học: " Responses of hyperthermophilic crenarchaea to UV irradiation"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Responses of hyperthermophilic crenarchaea to UV irradiation. | Open Access Research Responses of hyperthermophilic crenarchaea to UV irradiation Dorothee Gotz Sonia Paytubi Stacey Munro Magnus Lundgren Rolf Bernander and Malcolm F White Addresses Aquapharm Bio-Discoveries European Centre for Marine Biotechnology Dunbeg Oban PA37 1QA UK. Centre for Biomolecular Sciences University of St Andrews North Haugh St Andrews KY16 9ST UK. Department of Molecular Evolution Uppsala University Norbyvagen 18C SE-752 36 Uppsala Sweden. Correspondence Malcolm F White. Email mfw2@st-and.ac.uk Published II October 2007 Genome Biology 2007 8 R220 doi I0.II86 gb-2007-8- I0-r220 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 I0 R220 Received 29 March 2007 Revised 9 August 2007 Accepted II October 2007 2007 Gotz et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background DNA damage leads to cellular responses that include the increased expression of DNA repair genes repression of DNA replication and alterations in cellular metabolism. Archaeal information processing pathways resemble those in eukaryotes but archaeal damage response pathways remain poorly understood. Results We analyzed the transcriptional response to UV irradiation in two related crenarchaea Sulfolobus solfataricus and Sulfolobus acidocaldarius. Sulfolobus species encounter high levels of DNA damage in nature as they inhabit high temperature aerobic environments and are exposed to sunlight. No increase in expression of DNA repair genes following UV irradiation was observed. There was however a clear transcriptional response including repression of DNA replication and chromatin proteins. Differential effects on the expression of the three transcription factor

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