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Báo cáo y học: "Profiling gene expression in growth-arrested mouse embryos in diapause"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Profiling gene expression in growth-arrested mouse embryos in diapause. | Minireview Profiling gene expression in growth-arrested mouse embryos in diapause Eiichi Hondo and Colin L Stewart Address Cancer and Developmental Biology Laboratory National Cancer Institute Division of Basic Science National Cancer Institute at Frederick Frederick MD 21702 USA. Correspondence Colin L Stewart. E-mail stewartc@ncifcrf.gov Published 21 December 2004 Genome Biology 2004 6 202 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2004 6 l 202 2004 BioMed Central Ltd Abstract In many mammalian species embryonic cell proliferation can be reversibly arrested in an embryonic diapause at the time of embryo implantation. A recent report has identified changes in embryonic gene expression that are associated with and may halt embryonic cell proliferation. We are all accustomed to the fact that most successful human pregnancies last approximately nine and a half months. But in some 100 mammalian species the duration of pregnancy can vary among individuals within the same species and even between pregnancies in a single individual. A variety of strategies have evolved for regulating the length of pregnancy ranging from the storage and timed release of sperm for fertilization following mating to delaying development of the implanted embryo as in some bat species. The most common method however is to allow the fertilized egg to develop to the blastocyst stage and then to arrest embryonic cell proliferation and metabolism. This arrest prevents the blastocyst from implanting into the uterus - an essential step for subsequent embryonic development. Implantational delay or embryonic diapause results in the blastocyst entering into a state of metabolic and proliferative quiescence. Once diapause is interrupted the blastocycst regains an active metabolism cell proliferation is initiated the blastocyst implants in the uterus and development continues Figure 1 . The precise role of diapause in the reproductive .