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Báo cáo sinh học: "Divergent selection for humoral immune responsiveness in chickens: distribution and effects of major histocompatibility complex types"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Divergent selection for humoral immune responsiveness in chickens: distribution and effects of major histocompatibility complex types | 191 Genet Sei Evol 1993 25 191-203 Elsevier INRA Original article Divergent selection for humoral immune responsiveness in chickens distribution and effects of major histocompatibility complex types . M-H Pinard1 JAM Van Arendonk2 MGB Nieuwland1 AJ Van der Zijpp3 1 -Department of Animal Husbandry Wageningen Agricultural University Wageningen 2 Department of Animal Breeding Wageningen Agricultural University Wageningen 3 DLO-Research Institute for Animal Production Schoonoord Zeist The Netherlands Received 13 April 1992 accepted 20 November 1992 Summary - Chickens were selected for 10 generations for high and low antibody response to sheep red blood cells in addition a randombred control line was maintained. All birds n 1 602 from the 9th and 10th generations were typed for major histocompatibility complex B-types. All identified types were present in the control line but the selected lines showed divergent distributions. The 121 B-haplotype was predominant in the high line in the form of 121-121 B-genotype whereas the 114 B-haplotype was most frequent in the form of 114-114 and 114-124 B-genotypes in the low line. To explain these frequency changes effects of B-genotypes on the selected trait were estimated using a mixed animal model. The B-genotypes were responsible for a significant part of variation of the trait within lines but their effects differed between lines. These effects could be related partly to the changes in B-genotype distribution. chicken immune response selection animal model major histocompatibility complex Resume Selection divergente sur la réponse immunitaire chez la poule distribution et effets des types du complexe majeur d histocompatibilite. Des poulets ont été sélectionnés pendant 10 generations sur la réponse immunitaire haute et basse à des globules rouges de mouton une lignée témoin était également maintenue par accouplements Correspondence and reprints MH Pinard Laboratoire de Génétique Factorielle INRA 78352 Jouy-en-Josas Cedex .