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Báo cáo sinh học: "Improve protective efficacy of a TB DNA-HSP65 vaccine by BCG priming"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Improve protective efficacy of a TB DNA-HSP65 vaccine by BCG priming | Genetic Vaccines and Therapy BioMed Central Research Open Access Improve protective efficacy of a TB DNA-HSP65 vaccine by BCG priming Eduardo DC Gonẹalves1 Vânia Luiza D Bonato1 Denise M da Fonseca1 Edson G Soares3 Izaira T Brandão2 Ana Paula M Soares2 and Célio L Silva 1 Address 1Farmacore Biotecnologia Ltda Rua dos Técnicos s n Campus da USP Ribeirão Preto SP Brazil 2Center for Tuberculosis Research Department of Biochemistry and Immunology School of Medicine of Ribeirão Preto University of São Paulo Brazil and 3Department of Pathology School of Medicine of Ribeirão Preto University of São Paulo Brazil Email Eduardo DC Gonẹalves - eduardo@farmacore.com.br Vânia Luiza D Bonato - vlbonato@fmrp.usp.br Denise M da Fonseca - denise@cpt.fmrp.usp.br Edson G Soares - egsoares@fmrp.usp.br IzairaT Brandão - izausp@cpt.fmrp.usp.br Ana Paula M Soares - masson@fmrp.usp.br Célio L Silva - clsilva@fmrp.usp.br Corresponding author Published 22 August 2007 Received 22 March 2007 Accepted 22 August 2007 Genetic Vaccines and Therapy 2007 5 7 doi l0.l 186 1479-0556-5-7 This article is available from http www.gvt-journal.cOm content 5 1 7 2007 Gonẹalves et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Vaccines are considered by many to be one of the most successful medical interventions against infectious diseases. But many significant obstacles remain such as optimizing DNA vaccines for use in humans or large animals. The amount of doses route and easiness of administration are also important points to consider in the design of new DNA vaccines. Heterologous prime-boost regimens probably represent the best hope for an improved DNA vaccine strategy. In this study we have shown that heterologous prime-boost vaccination against .