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Báo cáo y học: " The histone deacetylase Rpd3p is required for transient changes in genomic expression in response to stress"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The histone deacetylase Rpd3p is required for transient changes in genomic expression in response to stress | Researc h Open Access The histone deacetylase Rpd3p is required for transient changes in genomic expression in response to stress Adriana L Alejandro-Osorio Dana J Huebert Dominic T Porcaro Megan E Sonntag Songdet Nillasithanukroh Jessica L Will and Audrey P Gasch Addresses Department of Biomolecular Chemistry University of Wisconsin-Madison University Avenue Madison WI 53706 USA. Program in Cellular and Molecular Biology University of Wisconsin-Madison Linden Drive Madison WI 53706 USA. Laboratory of Genetics University of Wisconsin-Madison Henry Mall Madison WI 53706 USA. Genome Center of Wisconsin University of Wisconsin-Madison Henry Mall Madison WI 53706 USA. Current address Booz Allen Hamilton Global Health Consulting Olive Way Seattle WA 98101 USA. H These authors contributed equally to this work. Correspondence Audrey P Gasch. Email agasch@wisc.edu Published 26 May 2009 Genome Biology 2009 10 R57 doi 10.1186 gb-2009- 10-5-r57 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2009 10 5 R57 Received 7 April 2009 Revised 13 May 2009 Accepted 26 May 2009 2009 Alejandro-Osorio et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Yeast responding to stress activate a large gene expression program called the Environmental Stress Response that consists of approximately 600 repressed genes and approximately 300 induced genes. Numerous factors are implicated in regulating subsets of Environmental Stress Response genes however a complete picture of Environmental Stress Response regulation remains unclear. We investigated the role of the histone deacetylase Rpd3p previously linked to the upstream regions of many Environmental Stress Response genes